Using xlsx with ArcPy?

I am writing a Python script that finds the difference between populations for U.S. counties from one year to another and writes that information to a new field in a xlxs file. Can it be done with ArcPy and what would the code look like? Below is a sample of the xlxs data with the column names:

Area_name, Resident population 1990, Resident population 2000, Resident population 2010 UNITED STATES, 248709873, 281421906, 308745538 ALABAMA, 4040587, 4447100, 4779736 Autauga, AL, 34222, 43671, 54571 Baldwin, AL, 98280, 140415, 182265 Barbour, AL, 25417, 29038, 27457 Bibb, AL, 16576, 20826, 22915 

I have the below code so far but I'm getting errors:

import arcpy from arcpy import env import xlrd env.workspace=r'C:\Users\Kevin\Desktop\Geoprograming\week_four' workbook = xlrd.open_workbook('test.xlsx') worksheet = workbook.sheet_names('sheet1') cursor = arcpy.da.UpdateCursor(population, ["1990", "2000"]) cursor.insertRow([diff90_10]) for row in cursor: row[diff90_10] = row[2010]-row[1990] cursor.updateRow([row]) 

Runtime error Traceback (most recent call last): File "", line 9, in File "C:\Python27\ArcGIS10.4\lib\site-packages\xlrd__init__.py", line 394, in open_workbook f = open(filename, "rb") IOError: [Errno 2] No such file or directory: 'test.xlsx'